Sclerosis (medicine)
For other uses, see Sclerosis (disambiguation). Not to be confused with Scoliosis. Sclerosis (medicine) Micrograph of subepithelial sclerosus (middle third of image) in a case of lichen sclerosus. H&E stain. Classification and external resources MeSH D012598 [edit on Wikidata] In medicine, sclerosis (also spelled sclerosus in the names of a few disorders; from Greek σκληρός "hard") is the stiffening of a structure, usually caused by a replacement of the normal organ-specific tissue with connective tissue. The structure may be said to have undergone sclerotic changes or display sclerotic lesions, which refers to the process of sclerosis. Common medical conditions whose pathology involves sclerosis include: Amyotrophic lateral sclerosis, sometimes known as Lou Gehrig's disease, a progressive, incurable, usually fatal disease of motor neurons. Atherosclerosis, a deposit of fatty materials, such as cholesterol, in the arteries which causes hardening. Focal segmental glo...